The Irish team's most recent international match was in June, where they were defeated 3-0 by Portugal.
England, meanwhile, will be playing for the first time since their loss in the final of the European Championships in July. The visitors will be travelling with interim manager Lee Carsley in charge of a new-look team that will be led by Harry Kane.
MORE: UEFA Nations League fixtures, results, schedule and format for European international football competition
The Sporting News looks at the key details ahead of this game, including how to watch the match, kickoff times and the latest lineup news.
Republic of Ireland vs. England live stream, TV channel in the UKHere's how to watch this UEFA Nations League match in UK:
TV channel: ITV 1 UK, STV Scotland, UTV
Live stream: ITVX, STV Player
This match is available for TV broadcast on ITV 1 UK, STV Scotland and UTV. Streaming options are available on ITVX and STV Player.
If the game is not available to watch live in your location, or if you’re traveling abroad, you can use a Virtual Private Network (VPN). VPNs offer a secure and private online connection, allowing you to bypass geographical restrictions to access your favorite streaming services from any device anywhere in the world.
WATCH FROM ANYWHERE: Sign up for NordVPN (30-day moneyback guarantee)
What time does Republic of Ireland vs. England kick off in the UK?This UEFA Nations League clash takes place at the Aviva Stadium in Dublin, Ireland and kicks off on Saturday, September 7 at 5:00 p.m. local time.
Here's how that time translates to in the UK:
DateKickoff timeBritish Summer TimeSat, Sept. 75:00 p.m.Republic of Ireland vs. England lineups, team newsGavin Bazunu and Josh Cullen are forced out with injury.
Ireland coach Heimir Hallgrimsson may hand a debut to Leicester City winger Kasey McAteer, who recently switched allegiance from England.
Republic of Ireland predicted XI (4-4-2, right to left): Kelleher (GK) — Coleman, O'Shea, Collins, Brady — Ogbene, Browne, Smallbone, O'Dowda — Ferguson, Idah.
Injured: Bazunu, Cullen
Suspended: —
The visitors will be without Phil Foden, Jude Bellingham, Ollie Watkins, Reece James and Luke Shaw.
Carsley however, has named a few of his Under-21 graduates for potential senior team debuts.
England predicted XI (4-2-3-1 right to left): Pickford (GK) — Alexander-Arnold, Stones, Maguire, Colwill — Rice, Mainoo — Saka, Eze, Gordon — Kane.
Injured: Foden, Bellingham, James, Shaw, Watkins
Suspended: —
A new-look England team has made the short trip to Dublin is stacked with talent. The visitors should be able to come away with a win against the Irish, who are struggling on the international stage. Ireland have won just one of their last six matches in all competitions.
Prediction: Republic of Ireland 0-2 England